Treatment Of Chronic Resistant Myeloid Leukemia.
NATIONAL JOURNAL OF HOMOEOPATHY 1995 Nov / Dec VOL VI NO 6.
Raghunadha Rao.
Cases.
` Ars / Phos / Ceon / Apis / Hydr / Livon.

Research Section:

CML is the commonest Leukaemia amongst all Haemotologic malignancies in India unlike the West where Chronic Lymphatic Leukaemia is more common. It is present in the elderly age group in the West the 4th, 5th and 6th decades whereas in India it present two decades earlier i.e. between the 3rd and 4th decade.

It classically runs in three phases -

1. Chronic phase
2. Accelerated phase
3. Blastic crisis

A majority of the patients present in the chronic phase with the predominant symptom being splenomegaly. The chronic phase usually lasts 1 year and six months and enters the accelerated phase where there is failure to respond to the drugs used in the chronic phase. The acute phase or blastic crisis cannot be differentiated from the acute denovo leukemia, acute phase can be lymphoid or myeloid and is usually non-responsive to treatment.

Drugs used in the chronic phase are Hydroxyurea and Busulphan. These drugs do not alter the natural history of CML, but offer only symptomatic relief, Interferons by virtue of being Biologic response modifiers do prolong the chronic phase and in about 30 percent can induce a complete haemotologic remission; they are not of equal benefit in accelerated and blastic crisis phases. In fact, there is no treatment for the accelerated phase except bone marrow transplantation.

We hereby describe 3 cases of CML in blastic crisis managed with Homoeopathic drugs. In one patient there was no response to treatment with allopathic drugs. The Homoeopathic drugs provided necessary symptomatic relief in the other two after initial remission induction therapy with an All protocol Mitoxantrone, Vincristine and Prednisolone for 8 weeks. Patients were maintained only on Homoeopathic drugs with complete haemotologic and clinical remission.

Homoeopathic Drugs Used:-

1. Ars-alb 200-1 dose was given to all the three as a starter.
2. Phosphorus 30-6 pills daily for 15 days every month.
3. Ceonanthus 0-1 Oz splenic regression.
4. Apis-mel -1 Oz pedal oedema.
5. Hydrastis 0-1 Oz as general anti neoplastic.
6. Syrup Livonip 2 tsp half an hour before food for anorexia.
7. Biochemic No.1 for rectifying anaemia. The effect of

Homoeopathic drugs on physical signs and haemotological parameters are tabled as follows:

CASE 1:

1. Heaviness and fullness of left hypochondrium.
2. Easy satiety.

17-9-93 22-10-94 23-2-95
HB; 11.7; 13.8; 6.1
TLC; 1,44,700; 39,000; 28,500
DLC; 22-9-93; 22-1-94; 11-4-95
BEA; Blast in In Blast
Crisis, Chronic-Phase, Crisis associated with marrow, Fibrosis
22-9-93, 6-4-94, 11-4-95
Spleen; huge, Splenomegaly, Decreased, Same As on 22-9-93

CASE 2:

1. Pain in the epigastric region - 30 days.
2. Tingling and numbness of the lower limbs - 3 months
3. Vincristine neuropathy.

30-7-93 6-9-94 9-10-95
HB; 8.7; 7.3; 9.5
TLC; 1,04,000; 86,000; 69,000
DLC; BL 8 percent, PROM, YELO 7 percent, 23-2-93; BL 10 percent, PROM, YELO 7 percent, 27-
1-94; BL 12 percent PROM YELO 23 percent 11- 10-95.
BMA; CML IN, Blast Crisis, 30-7-93; CML IN, Chronic Phase, 19-8-99; Relapsed in Blast crisis, 9-10-95.
SPLEEN; 4 CMs; NOT Palpable; 10 CMs.

CASE 3:

1. Giddiness anorexia malaise backache.
2. Peripheral neuropathy.
3. Vincristine neuropathy.

7-4-94 4-9-95
HB 7.5 13.1
TLC 4,200 10,400
DLC
28-2-94 15-4-94 17-5-95
BMA CML IN CML IN CML IN
BLAST CHRONIC CHRONIC
CRISIS PHASE PHASE
SPLEEN 10 CMs Not Palpable Not Palpable.
Gained weight by 6 Kilos off drugs since 7-4-95 on only Homoeopathy.

RESULTS and CONCLUSIONS:

1. One patient died after 2 years.
2. One patient had relapse after 2 and 1-2 years,
3. One is in complete haemotologic and clinical remission.
4. No allopathic drugs used for the past 1 and a 1-2 years in the third case,
5. Al three had good quality of life with relief of symptoms.
6. Homoeopathic drugs as used above have significant effect in prolonging and maintaining the chronic phase of CML.

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